Research, Projects and Papers
Dr. Karl Deisseroth
- Projects:
- Optogenetics: Dr. Deisseroth pioneered the development and application of optogenetics, a technique that uses light to control cells in living tissue, enabling precise manipulation of neural activity.
- Papers:
- “Optogenetics: 10 years of microbial opsins in neuroscience” (2015): A review paper discussing the evolution and impact of optogenetic tools in neuroscience research.
- “Circuit dynamics of adaptive and maladaptive behaviour” (2016): A study exploring neural circuit dynamics underlying adaptive and maladaptive behaviors using optogenetic techniques.
- “An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology” (2008): A paper detailing the development of an optical neural interface for controlling motor cortex activity in rodents.
- Work:
- Neural Circuit Mapping: Dr. Deisseroth’s work includes mapping neural circuits involved in behavior, cognition, and psychiatric disorders using optogenetic and imaging techniques.
- Behavioral Neuroscience: His research investigates the neural basis of behavior, emotions, and psychiatric conditions, offering insights into brain circuitry and potential therapeutic targets.
Dr. Li-Huei Tsai
- Projects:
- Neuroprosthetics: Dr. Tsai’s research focuses on developing neuroprosthetic devices and brain-machine interfaces to restore neural function and enhance cognitive abilities in neurological disorders.
- Epigenetics and Memory Formation: Her work explores the role of epigenetic mechanisms in memory formation, synaptic plasticity, and cognitive aging.
- Papers:
- “Epigenetic regulation in memory and cognitive disorders” (2014): A review paper discussing epigenetic mechanisms underlying memory processes and their dysregulation in cognitive disorders.
- “Harnessing neurogenesis for brain repair and regeneration” (2019): A paper exploring strategies for harnessing neurogenesis as a potential therapeutic approach for brain repair and regeneration.
- “Optical control of neural circuits: using light to manipulate the mammalian brain” (2005): A pioneering study on using optical methods to manipulate neural circuits and control brain activity.
- Work:
- Alzheimer’s Disease Research: Dr. Tsai’s research includes investigating the molecular mechanisms of Alzheimer’s disease, with a focus on tau protein pathology and cognitive decline.
- Neuroregeneration: Her work also delves into neuroregeneration strategies, including stem cell therapies, neurotrophic factors, and neuroprotective interventions for brain repair.
Both Dr. Karl Deisseroth and Dr. Li-Huei Tsai have made significant contributions to neuroscience, neuroengineering, and cognitive research, advancing our understanding of brain function, neural circuits, and neurological disorders through their projects, papers, and innovative work.